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Researchers Uncover New Demiguisin Peptides with Anti-Mycobacterial Potential

Researchers Uncover New Demiguisin Peptides with Anti-Mycobacterial Potential

Using targeted pathway mining in Amycolatopsis strains, scientists isolated five new demiguisin hexapeptides with distinct piperazic acid modifications. Two compounds showed potent activity against Mycobacterium intracellulare and moderate activity against Mycobacterium tuberculosis.

Original headline

Targeted pathway mining reveals novel modified hexapeptides from the demiguisin family

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